The incidence of syphilis in American women doubled between 2012 and 2016, and the incidence of congenital syphilis rose concomitantly. Congenital syphilis can lead to stillbirth, neonatal death, and lasting effects such as bone deformities and neurologic impairment in the newborn. Because of this, the USPSTF has reiterated its guidance that all pregnant women be tested for syphilis at their first prenatal visit. They also point out that many organizations recommend repeat testing of high-risk women in the third trimester and at delivery.
US Preventive Services Task Force, 2018
Evidence Rating: II
Prenatal Care and Education STDs including HIV
Clinical Guidelines/Expert Recommendations for Providers